Two persons have been confirmed dead in Lukula in the North Gonja District of the Savannah Region.
The two are reported to have been killed in a renewed land dispute between two Mamprusi factions over the siting of a mosque.
Four others are said to have also sustained various degrees of wounds.
According to reports, the incident occurred on Thursday night and lasted some minutes.
A resident, Mahama Asafo Musah, in a telephone interview indicated that the incident was triggered by a misunderstanding over the construction of a mosque in the area.
He added that one faction in the area wanted to build a mosque and the other resisted their attempts resulting in the clash.
Savannah Regional Minister Salifu Adam Braimah confirmed the incident and said the violence originated from a land dispute and that he is working with the District Security Council (DISEC) to resolve it.
More police personnel have been deployed to beef up security in the area.
Meanwhile, reports indicate the town has been deserted.
By Christopher Amoako|3news.com|Ghana